Lily Tomlin

Ms. Frizzle (voice)

Max Beckford

Tim (voice)

Daniel DeSanto

Carlos (voice)

Stuart Stone

Ralphie (voice)

Amos Crawley

Arnold (voice)

Danny Tamberelli

Arnold Perlstein (voice)

Erica Luttrell

Keesha (voice)

Lisa Yamanaka

Wanda (voice)

Tara Meyer

Dorothy Ann (voice)

Maia Filar

Phoebe (voice)

Andre Ottley-Lorant

Tim (voice)

Malcolm-Jamal Warner

The Producer (voice)